Objectives: To assess whether low-dose contrast medium and low-tube voltage computed tomography (CT) venography can be used for clinical diagnosis.
Methods: This prospective study included 63 patients who were randomized into 3 groups and administered contrast medium of either 600, 500, or 400 mg of iodine per kilogram (mgI/kg). All patients underwent dual-energy CT at either 80 or 135 kilovolt (peak) (kV[p]). Control images (120 kV[p]) were acquired from them and were compared with 80-kV(p) images. The mean CT values of the bilateral femoral and popliteal veins were compared.
Results: The mean CT values of the 80-kV(p) images were significantly higher than 120-kV(p) images for all doses. No significant difference was observed for the CT values of the 80-kV(p) images with the 400-mgI/kg dose and the control images (600 mgI/kg at 120 kV[p]).
Conclusions: Low tube voltage enabled a reduction of contrast medium to 400 mgI/kg for CT venography.