Computed tomography (CT) venography with dual-energy CT: low tube voltage and dose reduction of contrast medium for detection of deep vein thrombosis

J Comput Assist Tomogr. Sep-Oct 2014;38(5):797-801. doi: 10.1097/RCT.0000000000000114.


Objectives: To assess whether low-dose contrast medium and low-tube voltage computed tomography (CT) venography can be used for clinical diagnosis.

Methods: This prospective study included 63 patients who were randomized into 3 groups and administered contrast medium of either 600, 500, or 400 mg of iodine per kilogram (mgI/kg). All patients underwent dual-energy CT at either 80 or 135 kilovolt (peak) (kV[p]). Control images (120 kV[p]) were acquired from them and were compared with 80-kV(p) images. The mean CT values of the bilateral femoral and popliteal veins were compared.

Results: The mean CT values of the 80-kV(p) images were significantly higher than 120-kV(p) images for all doses. No significant difference was observed for the CT values of the 80-kV(p) images with the 400-mgI/kg dose and the control images (600 mgI/kg at 120 kV[p]).

Conclusions: Low tube voltage enabled a reduction of contrast medium to 400 mgI/kg for CT venography.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Contrast Media / administration & dosage
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Female
  • Humans
  • Iopamidol / administration & dosage*
  • Male
  • Middle Aged
  • Phlebography / methods*
  • Radiation Dosage*
  • Radiation Protection / methods
  • Radiography, Dual-Energy Scanned Projection / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Tomography, X-Ray Computed / methods*
  • Venous Thrombosis / diagnostic imaging*


  • Contrast Media
  • Iopamidol