Ultrastructural fingerprints of avian influenza A (H7N9) virus in infected human lung cells

Virology. 2014 May;456-457:39-42. doi: 10.1016/j.virol.2014.03.013. Epub 2014 Mar 28.


In this study, we investigated the ultrastructural modifications induced by influenza A (H7N9) virus in human lung epithelial cells. One particular characteristic of H7N9 viral infection is the formation of numerous M1-associated striated tubular structures within the nucleus and the cytoplasm, which have only previously been observed for a limited number of influenza A viruses, notably the 2009 pandemic (H1N1) virus.

Keywords: H7N9; Host cellular ultrastructure; Infection fingerprints; Influenza virus; M1; Matrix protein; Orthomyxoviridae; Viruses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Cell Nucleus / ultrastructure
  • Cytoplasm / ultrastructure
  • Epithelial Cells / ultrastructure*
  • Epithelial Cells / virology*
  • Humans
  • Influenza A Virus, H7N9 Subtype / ultrastructure*
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Microscopy, Immunoelectron
  • Microtubules / ultrastructure