Stem cells loaded with nanoparticles as a drug carrier for in vivo breast cancer therapy

Adv Mater. 2014 Jul 16;26(27):4627-31. doi: 10.1002/adma.201401550. Epub 2014 May 30.

Abstract

A novel anti-cancer drug carrier, mesenchymal stem cells (MSCs) encapsulating drug-loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor-affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.

Keywords: cancer; mesenchymal stem cells (MSCs); nanoparticles; photodynamic therapy; photosensitizers.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology*
  • Cell Line, Tumor
  • Drug Carriers / chemistry*
  • Humans
  • MCF-7 Cells
  • Mesenchymal Stem Cells*
  • Nanoparticles / chemistry*
  • Photochemotherapy / methods*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology
  • Photosensitizing Agents / therapeutic use

Substances

  • Drug Carriers
  • Photosensitizing Agents