Inosine octamer stabilized by alkali earth metal cations - as studied by electrospray ionization mass spectrometry

Eur J Mass Spectrom (Chichester). 2014;20(3):249-53. doi: 10.1255/ejms.1276.


By using electrospray ionization mass spectrometry, inosine was found to be able to form an octamer stabilized by alkali earth metal cation, namely Ca(2+), Sr(2+) and Ba(2+), of which the most stable is that stabilized by Ca(2+) (ion [I8+Ca](2+)). It was established that 9-methylhypoxanthine (M) did not form an analogical octamer, since ion [M8+Ca](2+) was not detected. On the other hand, 9-methylhypoxanthine can form "mixed" octamers together with inosine (ions [InMm+Ca](2+), n + m = 8, were detected).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Barium / chemistry
  • Calcium / chemistry
  • Cations / chemistry
  • Hypoxanthines / chemistry*
  • Inosine / chemistry*
  • Metals, Alkali / chemistry*
  • Spectrometry, Mass, Electrospray Ionization / methods
  • Strontium / chemistry


  • 9-methylhypoxanthine
  • Cations
  • Hypoxanthines
  • Metals, Alkali
  • Barium
  • Inosine
  • Calcium
  • Strontium