Clinical and laboratory characteristics of central nervous system herpes simplex virus infection in neonates and young infants

Pediatr Infect Dis J. 2014 Nov;33(11):1187-9. doi: 10.1097/INF.0000000000000433.

Abstract

We reviewed the characteristics of infants <3 months of age with central nervous system herpes simplex virus infection at our institution. Twenty-six cases were identified. The age range was 4-73 days. Most infants presented with fever, seizure activity and skin lesions. The blood herpes simplex virus polymerase chain reaction was positive in 91% of patients tested. Suppressive oral acyclovir therapy was likely helpful in preventing disease recurrence.

MeSH terms

  • Acyclovir / therapeutic use
  • Antiviral Agents / therapeutic use
  • Cerebrospinal Fluid / virology
  • Fever / virology
  • Herpes Simplex / blood
  • Herpes Simplex / complications*
  • Herpes Simplex / drug therapy
  • Humans
  • Infant
  • Infant, Newborn
  • Magnetic Resonance Imaging
  • Meningoencephalitis / blood
  • Meningoencephalitis / drug therapy
  • Meningoencephalitis / virology*
  • Retrospective Studies
  • Seizures / virology
  • Skin Diseases, Viral / virology

Substances

  • Antiviral Agents
  • Acyclovir