Adult type granulosa cell tumor of the testis with a heterologous sarcomatous component: case report and review of the literature

Diagn Pathol. 2014 Jun 3:9:107. doi: 10.1186/1746-1596-9-107.


Adult testicular granulosa cell tumors are rare sex cord- stromal tumors of which only 45 have been previously reported. As compared with their ovarian counterparts, these tumors may follow a more aggressive course because the proportion of malignant cases is higher. We report here a unique case of a 78-year Caucasian with a left sided adult type granulosa cell tumor with a heterologous sarcomatous tumor component. A heterologous sarcomatous component has occasionally been observed in ovarian tumors but never in testicular granulosa cell tumors. The sarcomatous component showed a higher number of mitotic figures (1/Hpf) and a marked proliferation rate (up to 50% Ki 67 positive cells) compared with the granulosa type tumor component. CD 99 and the progesterone receptor were positive in both tumor components, inhibin and calretinin only in the granulosa cells, and pancytokeratin only in the sarcomatouse one. Key words: testis - ovary - granulosa cells - sarcoma - inhibin Runing title: testicular sarcomatous granulosa tumor.

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Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Biomarkers, Tumor / analysis
  • Granulosa Cell Tumor / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasms, Complex and Mixed / pathology*
  • Sarcoma / pathology*
  • Testicular Neoplasms / pathology*


  • Biomarkers, Tumor