Targeted delivery of miRNA therapeutics for cardiovascular diseases: opportunities and challenges

Clin Sci (Lond). 2014 Sep;127(6):351-65. doi: 10.1042/CS20140005.


Dysregulation of miRNA expression has been associated with many cardiovascular diseases in animal models, as well as in patients. In the present review, we summarize recent findings on the role of miRNAs in cardiovascular diseases and discuss the opportunities, possibilities and challenges of using miRNAs as future therapeutic targets. Furthermore, we focus on the different approaches that can be used to deliver these newly developed miRNA therapeutics to their sites of action. Since siRNAs are structurally homologous with the miRNA therapeutics, important lessons learned from siRNA delivery strategies are discussed that might be applicable to targeted delivery of miRNA therapeutics, thereby reducing costs and potential side effects, and improving efficacy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / genetics
  • Cardiovascular Diseases / immunology
  • Disease Models, Animal
  • Humans
  • MicroRNAs / immunology
  • MicroRNAs / metabolism
  • MicroRNAs / therapeutic use*
  • Molecular Targeted Therapy* / methods
  • RNA, Small Interfering / immunology
  • RNA, Small Interfering / metabolism*
  • RNA, Small Interfering / therapeutic use
  • Treatment Outcome


  • MicroRNAs
  • RNA, Small Interfering