Leaky vaccines protect highly exposed recipients at a lower rate: implications for vaccine efficacy estimation and sieve analysis

Comput Math Methods Med. 2014:2014:813789. doi: 10.1155/2014/813789. Epub 2014 May 7.

Abstract

"Leaky" vaccines are those for which vaccine-induced protection reduces infection rates on a per-exposure basis, as opposed to "all-or-none" vaccines, which reduce infection rates to zero for some fraction of subjects, independent of the number of exposures. Leaky vaccines therefore protect subjects with fewer exposures at a higher effective rate than subjects with more exposures. This simple observation has serious implications for analysis methodologies that rely on the assumption that the vaccine effect is homogeneous across subjects. We argue and show through examples that this heterogeneous vaccine effect leads to a violation of the proportional hazards assumption, to incomparability of infected cases across treatment groups, and to nonindependence of the distributions of the competing failure processes in a competing risks setting. We discuss implications for vaccine efficacy estimation, correlates of protection analysis, and mark-specific efficacy analysis (also known as sieve analysis).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • AIDS Vaccines / therapeutic use
  • Algorithms
  • Communicable Disease Control
  • Placebos
  • Proportional Hazards Models
  • Randomized Controlled Trials as Topic
  • Reproducibility of Results
  • Research Design
  • Risk
  • Vaccines / chemistry*
  • Vaccines / therapeutic use*

Substances

  • AIDS Vaccines
  • Placebos
  • Vaccines