ADAMTS-18: a metalloproteinase with multiple functions

Front Biosci (Landmark Ed). 2014 Jun 1;19:1456-67. doi: 10.2741/4296.

Abstract

ADAMTS-18 is a member of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family of proteases, which are known to play important roles in development, angiogenesis and coagulation; dysregulation and mutation of these enzymes have been implicated in many disease processes, such as inflammation, cancer, arthritis and atherosclerosis. Mutations of ADAMTS-18 have been linked to abnormal early eye development and reduced bone mineral density. In this review, we briefly summarize the structural organization and the expression of ADAMTS-18. We will also focus on the emerging role of ADAMTS-18 in several pathophysiological conditions which include: hematological diseases, tumorgenesis, osteogenesis, eye-related diseases, central nervous system disorders, and last but not least a research perspective of ADAMTS-18 and its potential as a promising diagnostic and therapeutic target.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ADAM Proteins / genetics*
  • ADAM Proteins / metabolism
  • ADAMTS Proteins
  • Bone Diseases / enzymology
  • Bone Diseases / genetics
  • Eye Diseases / enzymology
  • Eye Diseases / genetics
  • Genetic Predisposition to Disease / genetics*
  • Hematologic Diseases / enzymology
  • Hematologic Diseases / genetics
  • Humans
  • Models, Genetic*
  • Mutation*
  • Neoplasms / enzymology
  • Neoplasms / genetics

Substances

  • ADAM Proteins
  • ADAMTS Proteins
  • ADAMTS18 protein, human