Father-son chats: inheriting stress through sperm RNA

Cell Metab. 2014 Jun 3;19(6):894-5. doi: 10.1016/j.cmet.2014.05.015.


Although mounting evidence in mammals suggests that certain ancestral environmental exposures can influence the phenotype in future generations, mechanisms underlying such intergenerational information transfer remain unclear. A recent report suggests that RNA isolated from sperm can inform offspring of a father's history of early life trauma (Gapp et al., 2014).

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Male
  • MicroRNAs / metabolism*
  • Spermatozoa*
  • Stress, Psychological / etiology*
  • Stress, Psychological / therapy*


  • MicroRNAs