Free radical-scavenging activities of oligomeric proanthocyanidin from Rhodiola rosea L. and its antioxidant effects in vivo

Nat Prod Res. 2014;28(24):2301-3. doi: 10.1080/14786419.2014.921786. Epub 2014 Jun 4.


This study aimed to determine the antioxidant activity of oligomeric proanthocyanidin from Rhodiola rosea L. (OPCRR). The free radical-scavenging activities exhibited by OPCRR, as determined by using 1,1-diphenyl-2-picrylhydrazyl, hydroxyl radical and superoxide anion (√[Formula: see text]) scavenging assays, were greater than that of vitamin C. The effects of OPCRR on the antioxidant enzymes activity and lipid peroxide content in vivo were evaluated through three observation biomarkers, including superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, heart, liver and brain tissues in mice. The OPCRR significantly enhanced the SOD and GSH-Px activities, and reduced the MDA content in mice. These results indicated that the OPCRR has a great potential to be a natural antioxidant due to its considerable antioxidant activities in vitro and in vivo.

Keywords: Rhodiola rosea L.; antioxidant activity; mice; oligomeric proanthocyanidin.

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / isolation & purification*
  • Antioxidants / pharmacology*
  • Biphenyl Compounds / pharmacology
  • Free Radical Scavengers / blood
  • Free Radical Scavengers / chemistry
  • Free Radical Scavengers / isolation & purification*
  • Free Radical Scavengers / pharmacology*
  • Glutathione Peroxidase / metabolism
  • Malondialdehyde / analysis
  • Malondialdehyde / blood
  • Mice
  • Picrates / pharmacology
  • Proanthocyanidins / blood
  • Proanthocyanidins / chemistry
  • Proanthocyanidins / isolation & purification*
  • Proanthocyanidins / pharmacology*
  • Rhodiola / chemistry*
  • Superoxide Dismutase / metabolism


  • Antioxidants
  • Biphenyl Compounds
  • Free Radical Scavengers
  • Picrates
  • Proanthocyanidins
  • Malondialdehyde
  • 1,1-diphenyl-2-picrylhydrazyl
  • Glutathione Peroxidase
  • Superoxide Dismutase