A useful scoring system for the prediction and management of delayed graft function following kidney transplantation from cadaveric donors

Kidney Int. 2014 Dec;86(6):1130-9. doi: 10.1038/ki.2014.188. Epub 2014 Jun 4.


Delayed graft function (DGF) is a common complication in kidney transplantation and is known to be correlated with short- and long-term graft outcomes. Here we explored the possibility of developing a simple tool that could predict with good confidence the occurrence of DGF and could be helpful in current clinical practice. We built a score, tentatively called DGFS, from a French multicenter and prospective cohort of 1844 adult recipients of deceased donor kidneys collected since 2007, and computerized in the Données Informatisées et VAlidées en Transplantation databank. Only five explicative variables (cold ischemia time, donor age, donor serum creatinine, recipient body mass index, and induction therapy) contributed significantly to the DGF prediction. These were associated with a good predictive capacity (area under the ROC curve at 0.73). The DGFS calculation is facilitated by an application available on smartphones, tablets, or computers at www.divat.fr/en/online-calculators/dgfs. The DGFS should allow the simple classification of patients according to their DGF risk at the time of transplantation, and thus allow tailored-specific management or therapeutic strategies.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Antilymphocyte Serum / administration & dosage
  • Area Under Curve
  • Body Mass Index
  • Cadaver
  • Child
  • Child, Preschool
  • Cohort Studies
  • Cold Ischemia / adverse effects
  • Creatinine / blood
  • Decision Support Techniques*
  • Delayed Graft Function / diagnosis*
  • Delayed Graft Function / etiology
  • Delayed Graft Function / therapy
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Induction Chemotherapy
  • Infant
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Mobile Applications
  • Predictive Value of Tests
  • Prospective Studies
  • ROC Curve
  • Risk Factors
  • Smartphone
  • Tissue Donors
  • Young Adult


  • Antilymphocyte Serum
  • Immunosuppressive Agents
  • Creatinine