Chlorpromazine-induced skin pigmentation with corneal and lens opacities

Cutis. 2014 May;93(5):247-50.

Abstract

Chlorpromazine is known to cause abnormal oculocutaneous pigmentation in sun-exposed areas. We present the case of a psychiatric patient who developed blue-gray pigmentation of the skin as well as corneal and lens opacities following 7 years of chlorpromazine treatment. Ten months after discontinuation of chlorpromazine, the skin discoloration and anterior lens deposits showed partial improvement, but the corneal deposits remained unchanged. A review of the literature on the reversibility of chlorpromazine-induced abnormal oculocutaneous pigmentation also is provided.

Publication types

  • Case Reports

MeSH terms

  • Antipsychotic Agents / adverse effects*
  • Chlorpromazine / adverse effects*
  • Cornea / drug effects*
  • Cornea / pathology
  • Corneal Opacity / chemically induced*
  • Corneal Opacity / pathology
  • Female
  • Humans
  • Pigmentation Disorders / chemically induced*
  • Pigmentation Disorders / pathology
  • Schizophrenia / drug therapy
  • Skin / drug effects*
  • Visual Acuity
  • Young Adult

Substances

  • Antipsychotic Agents
  • Chlorpromazine