Aortic valve disease

Int J Clin Pract. 2014 Oct;68(10):1209-15. doi: 10.1111/ijcp.12471. Epub 2014 Jun 4.


Aortic valve disease is common and has significant impact on prognosis and quality of life. In this educational review, we cover the pathophysiology, presentation and assessment of aortic stenosis (AS) and aortic regurgitation (AR), including the role of imaging modalities beyond echocardiography. We review current treatment strategies and emphasise the use and indications for transcatheter aortic valve implantation (TAVI) in view of recent data highlighting its emergence as a novel treatment option for patients with AS, who are unsuitable for conventional aortic valve replacement (AVR). We also describe novel surgical approaches for AR and potential future strategies for percutaneous intervention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aortic Valve / pathology
  • Aortic Valve / surgery
  • Aortic Valve Stenosis / diagnosis
  • Aortic Valve Stenosis / diagnostic imaging
  • Bicuspid Aortic Valve Disease
  • Cardiac Catheterization / statistics & numerical data*
  • Heart Defects, Congenital / diagnosis
  • Heart Defects, Congenital / pathology*
  • Heart Defects, Congenital / surgery
  • Heart Defects, Congenital / therapy
  • Heart Valve Diseases / diagnosis
  • Heart Valve Diseases / pathology*
  • Heart Valve Diseases / surgery
  • Heart Valve Diseases / therapy
  • Heart Valve Prosthesis Implantation / adverse effects*
  • Heart Valve Prosthesis Implantation / methods
  • Humans
  • Quality of Life*
  • Treatment Outcome
  • Ultrasonography
  • Ventricular Function, Left / physiology*