Mortality of tuberculosis patients during treatment in Israel, 2000-2010

Int J Tuberc Lung Dis. 2014 Jul;18(7):818-23. doi: 10.5588/ijtld.13.0591.


Setting: Tuberculosis (TB) epidemiology in Israel is similar to that reported from other industrialised countries where most patients are foreign-born.

Objectives: To assess TB case fatality rate (CFR) and mortality trends during treatment and to identify risk factors associated with mortality.

Design: Retrospective cohort study of all TB patients in Israel diagnosed between 2000 and 2010. Cause of death was classified by TB-specific and non-TB-specific causes.

Results: During the study period, 451 TB patients died during treatment, representing a CFR of 9.9%. Of these, 72.5% died due to TB-related causes, giving a TB-related CFR of 7.2%. Both the overall and TB-related CFR decreased over the study period. Risk factors for death included male sex, older age, human immunodeficiency virus coinfection, culture positivity and multidrug-resistant TB (MDR-TB). Patients aged ≥65 years comprised 70% of the TB-related deaths, and more than half of these (54.9%) were born in the former Soviet Union, Europe (excluding the former Soviet Union) or the USA.

Conclusion: Both the overall and TB-related CFR decreased over the study period. Physicians who treat older male TB patients with MDR-TB or HIV should increase the index of suspicion to include the possibility of a higher risk of mortality.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Antitubercular Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Cohort Studies
  • Emigrants and Immigrants / statistics & numerical data
  • Female
  • HIV Infections / epidemiology*
  • Humans
  • Infant
  • Israel / epidemiology
  • Male
  • Middle Aged
  • Retrospective Studies
  • Risk Factors
  • Sex Factors
  • Tuberculosis / drug therapy
  • Tuberculosis / epidemiology
  • Tuberculosis / mortality*
  • Tuberculosis, Multidrug-Resistant / drug therapy
  • Tuberculosis, Multidrug-Resistant / epidemiology
  • Tuberculosis, Multidrug-Resistant / mortality*
  • Young Adult


  • Antitubercular Agents