A Case of Linear Atrophoderma of Moulin Successfully Treated With Methotrexate

Dermatol Ther. May-Jun 2014;27(3):153-5. doi: 10.1111/dth.12099. Epub 2013 Oct 8.


Linear atrophoderma of Moulin is an acquired rare and self-limited skin condition. It is characterized by atrophic bandlike skin lesions that often show hyperpigmentation and always follow the lines of Blaschko. Usually it begins in childhood or adolescence and there is no evidence of any long term progression. We describe a case of a 21-year-old woman with clinical and histological features of linear atrophoderma of Moulin. The patient was successfully treated with methotrexate 20 mg/week during 6 months with an improvement of skin pigmentation and atrophy. Approximately, 30 cases of linear atrophoderma of Moulin were described in the literature. There is not a proven effective treatment of this dermatosis. High dose penicillin, topical corticosteroids, heparin, and oral potassium aminobenzoate have been used but found to be uneffective. To our knowledge, this is the first case of extensive linear atrophoderma of Moulin treated with methotrexate.

Keywords: linear atrophoderma; methotrexate; treatment.

Publication types

  • Case Reports

MeSH terms

  • Atrophy
  • Dermatologic Agents / therapeutic use*
  • Female
  • Humans
  • Hyperpigmentation / diagnosis
  • Hyperpigmentation / drug therapy*
  • Methotrexate / therapeutic use*
  • Skin / drug effects*
  • Skin / pathology
  • Skin Diseases / diagnosis
  • Skin Diseases / drug therapy*
  • Skin Pigmentation / drug effects*
  • Time Factors
  • Treatment Outcome
  • Young Adult


  • Dermatologic Agents
  • Methotrexate