Mitochondrial perturbation negatively affects auxin signaling

Mol Plant. 2014 Jul;7(7):1138-50. doi: 10.1093/mp/ssu071. Epub 2014 Jun 5.


Mitochondria are crucial players in the signaling and metabolic homeostasis of the plant cell. The molecular components that orchestrate the underlying processes, however, are largely unknown. Using a chemical biology approach, we exploited the responsiveness of Arabidopsis UDP-glucosyltransferase-encoding UGT74E2 towards mitochondrial perturbation in order to look for novel mechanisms regulating mitochondria-to-nucleus communication. The most potent inducers of UGT74E2 shared a (2-furyl)acrylate (FAA) substructure that negatively affected mitochondrial function and was identified before as an auxin transcriptional inhibitor. Based on these premises, we demonstrated that perturbed mitochondria negatively affect the auxin signaling machinery. Moreover, chemical perturbation of polar auxin transport and auxin biosynthesis was sufficient to induce mitochondrial retrograde markers and their transcript abundance was constitutively elevated in the absence of the auxin transcriptional activators ARF7 and ARF19.

Keywords: auxin signaling; mitochondrial perturbation; retrograde communication..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylates / pharmacology
  • Arabidopsis / cytology
  • Arabidopsis / drug effects
  • Arabidopsis / genetics
  • Arabidopsis Proteins / genetics
  • Indoleacetic Acids / metabolism*
  • Mitochondria / drug effects
  • Mitochondria / metabolism*
  • Regulatory Sequences, Nucleic Acid / drug effects
  • Regulatory Sequences, Nucleic Acid / genetics
  • Signal Transduction* / drug effects


  • Acrylates
  • Arabidopsis Proteins
  • Indoleacetic Acids
  • acrylic acid