Phagosomal TLR signaling upon Borrelia burgdorferi infection

Front Cell Infect Microbiol. 2014 May 20;4:55. doi: 10.3389/fcimb.2014.00055. eCollection 2014.

Abstract

Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.

Keywords: Borrelia burgdorferi; Lyme disease; innate immunity; phagosomal signaling; toll-like receptors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Borrelia burgdorferi / immunology*
  • Humans
  • Lyme Disease / immunology
  • Lyme Disease / microbiology
  • Phagocytes / immunology
  • Phagocytes / microbiology
  • Phagosomes / immunology*
  • Phagosomes / microbiology*
  • Signal Transduction*
  • Toll-Like Receptors / immunology*
  • Toll-Like Receptors / metabolism

Substances

  • Toll-Like Receptors