Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging

Christopher Hine; James R Mitchell

doi:10.1016/j.stem.2014.05.016

Saying no to drugs: fasting protects hematopoietic stem cells from chemotherapy and aging

Cell Stem Cell. 2014 Jun 5;14(6):704-5. doi: 10.1016/j.stem.2014.05.016.

Authors

Christopher Hine¹, James R Mitchell²

Affiliations

¹ Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA.
² Department of Genetics and Complex Diseases, Harvard School of Public Health, Boston, MA 02115, USA. Electronic address: jmitchel@hsph.harvard.edu.

Abstract

Aging and chemotherapeutics damage hematopoietic stem cells (HSCs), leading to dysregulation of asymmetric division and subsequent immunosuppression and blood-related diseases. In this issue, Cheng et al. (2014) use prolonged fasting as a medical intervention to decrease IGF-1/PKA signaling and protect HSCs against chemotherapeutic toxicity and promote rejuvenation.

Publication types

Comment

MeSH terms

Animals
Cyclic AMP-Dependent Protein Kinases / metabolism*
Fasting / physiology*
Hematopoietic Stem Cells / cytology*
Hematopoietic Stem Cells / metabolism*
Immunosuppression Therapy*
Insulin-Like Growth Factor I / metabolism*
Regeneration*

Substances

insulin-like growth factor-1, mouse
Insulin-Like Growth Factor I
Cyclic AMP-Dependent Protein Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding