First identification and quantification of lorcaserin in an herbal slimming dietary supplement

J Pharm Biomed Anal. 2014 Sep;98:94-9. doi: 10.1016/j.jpba.2014.05.003. Epub 2014 May 14.


The weight-loss drug lorcaserin, a FDA approved anorectic drug, was isolated from the dietary supplement "Lose quickly" claimed to be a pure natural fast slimming diet pill. After its purification by means of preparative liquid chromatography, its structure was characterized using LC-UV, NMR, MS, MS/MS, and IR spectroscopy. The amount of lorcaserin measured by qNMR was 6.6mg/capsule.

Keywords: Adulteration; Lorcaserin; Mass Spectrometry (MS); Nuclear Magnetic Resonance (NMR); Slimming dietary supplements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzazepines / chemistry*
  • Chromatography, Liquid / methods
  • Dietary Supplements / analysis*
  • Herbal Medicine / methods
  • Magnetic Resonance Spectroscopy / methods
  • Tandem Mass Spectrometry / methods


  • Benzazepines
  • lorcaserin