[Idiopathic intracranial hypertension and factor V Leiden mutation]

Abstract

Activated proteinC resistance is a frequent prothrombotic abnormality. In most cases it is due to factorV Leiden mutation by nucleotide G1691A substitution. This recently described thrombophilic defect of activated proteinC resistance has been postulated to be implicated in the pathogenesis of idiopathic intracranial hypertension (IIH). We report a case of factorV Leiden mutation in association with IIH and their likely link and implication in the management of IIH.

Keywords: Activated protein C resistance; Facteur V Leiden; Factor V Leiden; Hypertension intracrânienne idiopathique; Idiopathic intracranial hypertension; Résistance à la protéine C activée; Thrombose; Thrombosis.