Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Jul;21(4):285-90.
doi: 10.1097/PAP.0000000000000022.

Arginase-1 Is a Novel Immunohistochemical Marker of Hepatocellular Differentiation

Affiliations
Review

Arginase-1 Is a Novel Immunohistochemical Marker of Hepatocellular Differentiation

Nelson G Ordóñez. Adv Anat Pathol. .

Abstract

Arginase-1 is an enzyme that catalyzes the hydrolysis of arginine to ornithine and urea in the urea cycle. In normal tissues, arginase-1 is primarily expressed in hepatocytes. Recent investigations have reported that the vast majority of hepatocellular carcinomas express this marker, but it is found only rarely in nonhepatocellular tumors. Owing to its restricted expression in hepatocellular carcinomas, arginase-1 has proved to be a useful immunohistochemical marker for assisting in distinguishing between these tumors and other neoplasms with which they may be confused.

Similar articles

See all similar articles

Cited by 4 articles

MeSH terms

LinkOut - more resources

Feedback