An evolving arsenal: viral RNA detection by RIG-I-like receptors

Curr Opin Microbiol. 2014 Aug;20:76-81. doi: 10.1016/j.mib.2014.05.004. Epub 2014 Jun 7.

Abstract

RIG-I-like receptors (RLRs) utilize a specialized, multi-domain architecture to detect and respond to invasion by a diverse set of viruses. Structural similarities among these receptors provide a general mechanism for double strand RNA recognition and signal transduction. However, each RLR has developed unique strategies for sensing the specific molecular determinants on subgroups of viral RNAs. As a means to circumvent the antiviral response, viruses escape RLR detection by degrading, or sequestering or modifying their RNA. Patterns of variation in RLR sequence reveal a continuous evolution of the protein domains that contribute to RNA recognition and signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD-box RNA Helicases / immunology
  • DEAD-box RNA Helicases / metabolism*
  • Host-Pathogen Interactions
  • Humans
  • Immune Evasion
  • RNA, Double-Stranded / immunology
  • RNA, Double-Stranded / metabolism*
  • RNA, Viral / immunology
  • RNA, Viral / metabolism*
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism*

Substances

  • RNA, Double-Stranded
  • RNA, Viral
  • Receptors, Immunologic
  • DEAD-box RNA Helicases