Copper Radical Oxidases and Related Extracellular Oxidoreductases of Wood-Decay Agaricomycetes

Fungal Genet Biol. 2014 Nov;72:124-130. doi: 10.1016/j.fgb.2014.05.011. Epub 2014 Jun 7.

Abstract

Extracellular peroxide generation, a key component of oxidative lignocellulose degradation, has been attributed to various enzymes including the copper radical oxidases. Encoded by a family of structurally related sequences, the genes are widely distributed among wood decay fungi including three recently completed polypore genomes. In all cases, core catalytic residues are conserved, but five subfamilies are recognized. Glyoxal oxidase, the most intensively studied representative, has been shown physiologically connected to lignin peroxidase. Relatively little is known about structure-function relationships among more recently discovered copper radical oxidases. Nevertheless, differences in substrate preferences have been observed in one case and the proteins have been detected in filtrates of various wood-grown cultures. Such diversity may reflect adaptations to host cell wall composition and changing environmental conditions.

Keywords: Brown rot; Glyoxal oxidase; Lignin; Lignin peroxidase; White rot.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Basidiomycota / enzymology*
  • Catalytic Domain
  • Conserved Sequence
  • Copper / metabolism*
  • Free Radicals / metabolism*
  • Models, Molecular
  • Oxidation-Reduction
  • Oxidoreductases / chemistry
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism*
  • Phylogeny
  • Protein Conformation
  • Sequence Homology

Substances

  • Free Radicals
  • Copper
  • Oxidoreductases