Objective: The aim of the article is to review the effectiveness of neonatal noninvasive high-frequency ventilation (NIHFV) in preventing endotracheal mechanical ventilation.
Study design: Retrospective case series including all 79 instances of NIHFV use at four participating centers between July 2010 and September 2012.
Results: In 73% of cases, NIHFV was used as rescue after another noninvasive mode, and prophylactically (postextubation) in the remainder. In 58% of cases, infants transitioned to another noninvasive mode, without requiring intubation. There were significant reductions in the mean (SD) number of apneas, bradycardias, or desaturations (over 6 hours) (3.2 [0.4] vs. 1.2 [0.3]; p < 0.001), FiO2 (48  vs. 40 %; p < 0.001) and CO2 levels (74  vs. 62  mm Hg; p = 0.025] with NIHFV. No NIHFV-related complications were noted.
Conclusions: NIHFV is a promising NIV mode that may help prevent or delay intubation and deserves further clinical research.
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