Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial

Nutr Res. 2014 May;34(5):420-7. doi: 10.1016/j.nutres.2014.03.006. Epub 2014 Apr 5.


Consumption of polyphenol-rich foods is associated with lower risk from many chronic diseases. We hypothesized that a single dose of cranberry beverage would improve indices of oxidative stress, inflammation, and urinary antibacterial adhesion activity in healthy humans. Six males and 6 females (18-35 years; body mass index, 19-25 kg/m(2)) consumed placebo, cranberry leaf extract beverage, or low-calorie cranberry juice cocktail (LCJC) once in a randomized, double-blind, placebo-controlled cross-over experimental design trial. The washout period between beverages was 1 week. Blood was collected 0, 2, 4, 8, and 24 hours after beverage consumption for measuring oxidative and inflammatory biomarkers. Urine was collected at 0, 0 to 3, 3 to 6, 6 to 9, 9 to 12, and 24 hours postintervention to assess antibacterial adhesion activity. Consumption of cranberry leaf extract beverage elevated (P < .05) blood glutathione peroxidase activity, whereas LCJC consumption increased (P < .05) glutathione concentrations and superoxide dismutase activity compared with placebo. Cranberry leaf extract beverage and LCJC consumption had no effect on the inflammatory biomarkers measured as compared with placebo. At 0 to 3 hours postconsumption, urine from participants who consumed cranberry beverages had higher (P < .05) ex vivo antiadhesion activity against P-fimbriated Escherichia coli compared with placebo. An acute dose of cranberry beverages improved biomarkers of antioxidant status and inhibition of bacterial adhesion in urine.

Keywords: Bacterial adhesion; Humans; Inflammation; Oxidative stress; Vaccinium macrocarpon.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Bacterial Adhesion / drug effects*
  • Beverages*
  • Cross-Over Studies
  • Double-Blind Method
  • Escherichia coli*
  • Female
  • Glutathione / blood
  • Glutathione Peroxidase / blood
  • Humans
  • Male
  • Oxidative Stress / drug effects*
  • Plant Leaves
  • Plant Preparations / pharmacology*
  • Polyphenols / pharmacology
  • Reference Values
  • Superoxide Dismutase / blood
  • Vaccinium macrocarpon / chemistry*


  • Anti-Bacterial Agents
  • Antioxidants
  • Plant Preparations
  • Polyphenols
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione