The ATP synthase inhibitor bedaquiline interferes with small-molecule efflux in Mycobacterium smegmatis

J Antibiot (Tokyo). 2014 Dec;67(12):835-7. doi: 10.1038/ja.2014.74. Epub 2014 Jun 11.

Authors

Ping Lu¹, Cristina Villellas², Anil Koul², Koen Andries², Holger Lill¹, Dirk Bald¹

Affiliations

¹ Department of Molecular Cell Biology and Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), VU University Amsterdam, Amsterdam, The Netherlands.
² Janssen Infectious Diseases, Johnson and Johnson, Turnhoutseweg, Beerse, Belgium.

PMID: 24916895
DOI: 10.1038/ja.2014.74

No abstract available

MeSH terms

ATP Synthetase Complexes / antagonists & inhibitors*
Antitubercular Agents / metabolism*
Diarylquinolines / pharmacology*
Enzyme Inhibitors / pharmacology*
Microscopy, Fluorescence
Mycobacterium Infections, Nontuberculous / drug therapy
Mycobacterium Infections, Nontuberculous / microbiology
Mycobacterium smegmatis / drug effects*
Mycobacterium smegmatis / metabolism

Substances

Antitubercular Agents
Diarylquinolines
Enzyme Inhibitors
bedaquiline
ATP Synthetase Complexes