The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

doi:10.1038/clpt.2014.125

Practice Guideline

. 2014 Oct;96(4):423-8.

doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11.

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

L B Ramsey¹, S G Johnson², K E Caudle¹, C E Haidar¹, D Voora³, R A Wilke⁴, W D Maxwell⁵, H L McLeod⁶, R M Krauss⁷, D M Roden⁸, Q Feng⁸, R M Cooper-DeHoff⁹, L Gong¹⁰, T E Klein¹⁰, M Wadelius¹¹, M Niemi¹²

Affiliations

¹ Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
² 1] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA [2] Clinical Pharmacy Services, Kaiser Permanente Colorado, Denver, Colorado, USA.
³ Department of Medicine, Duke University, Durham, North Carolina, USA.
⁴ 1] IMAGENETICS, Sanford Medical Center, Fargo, North Dakota, USA [2] Department of Medicine, University of North Dakota, Fargo, North Dakota, USA.
⁵ Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy, Columbia, South Carolina, USA.
⁶ Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA.
⁷ Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
⁸ 1] Oates Institute for Experimental Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA [2] Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
⁹ Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
¹⁰ Department of Genetics, Stanford University, Palo Alto, California, USA.
¹¹ Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
¹² 1] Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland [2] King Abdulaziz University , Jeddah, Saudi Arabia.

PMID: 24918167
PMCID: PMC4169720
DOI: 10.1038/clpt.2014.125

Practice Guideline

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

L B Ramsey et al. Clin Pharmacol Ther. 2014 Oct.

. 2014 Oct;96(4):423-8.

doi: 10.1038/clpt.2014.125. Epub 2014 Jun 11.

Authors

Affiliations

¹ Pharmaceutical Sciences Department, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
² 1] Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Denver, Colorado, USA [2] Clinical Pharmacy Services, Kaiser Permanente Colorado, Denver, Colorado, USA.
³ Department of Medicine, Duke University, Durham, North Carolina, USA.
⁴ 1] IMAGENETICS, Sanford Medical Center, Fargo, North Dakota, USA [2] Department of Medicine, University of North Dakota, Fargo, North Dakota, USA.
⁵ Department of Clinical Pharmacy and Outcomes Sciences, South Carolina College of Pharmacy, Columbia, South Carolina, USA.
⁶ Personalized Medicine Institute, Moffitt Cancer Center, Tampa, Florida, USA.
⁷ Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, California, USA.
⁸ 1] Oates Institute for Experimental Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA [2] Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University, Nashville, Tennessee, USA.
⁹ Department of Pharmacotherapy and Translational Research, Center for Pharmacogenomics and Division of Cardiovascular Medicine, University of Florida, Gainesville, Florida, USA.
¹⁰ Department of Genetics, Stanford University, Palo Alto, California, USA.
¹¹ Department of Medical Sciences, Clinical Pharmacology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
¹² 1] Department of Clinical Pharmacology, University of Helsinki and HUSLAB, Helsinki University Central Hospital, Helsinki, Finland [2] King Abdulaziz University , Jeddah, Saudi Arabia.

PMID: 24918167
PMCID: PMC4169720
DOI: 10.1038/clpt.2014.125

Abstract

Simvastatin is among the most commonly used prescription medications for cholesterol reduction. A single coding single-nucleotide polymorphism, rs4149056T>C, in SLCO1B1 increases systemic exposure to simvastatin and the risk of muscle toxicity. We summarize evidence from the literature supporting this association and provide therapeutic recommendations for simvastatin based on SLCO1B1 genotype. This article is an update to the 2012 Clinical Pharmacogenetics Implementation Consortium guideline for SLCO1B1 and simvastatin-induced myopathy.

Trial registration: ClinicalTrials.gov NCT01894230.

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References

1. Wilke R.A., et al. Clinical Pharmacogenomics Implementation Consortium (CPIC) The Clinical Pharmacogenomics Implementation Consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther. 2012;92:112–117. - PMC - PubMed
1. Wilke R.A., et al. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat. Rev. Drug Discov. 2007;6:904–916. - PMC - PubMed
1. Buettner C., Rippberger M.J., Smith J.K., Leveille S.G., Davis R.B., Mittleman M.A. Statin use and musculoskeletal pain among adults with and without arthritis. Am. J. Med. 2012;125:176–182. - PMC - PubMed
1. Wilke R.A., Dolan M.E. Genetics and variable drug response. JAMA. 2011;306:306–307. - PMC - PubMed
1. Ramsey L.B., et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012;22:1–8. - PMC - PubMed

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[1] Wilke R.A., et al. Clinical Pharmacogenomics Implementation Consortium (CPIC) The Clinical Pharmacogenomics Implementation Consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther. 2012;92:112–117. - PMC - PubMed

[2] Wilke R.A., et al. Clinical Pharmacogenomics Implementation Consortium (CPIC) The Clinical Pharmacogenomics Implementation Consortium: CPIC guideline for SLCO1B1 and simvastatin-induced myopathy. Clin. Pharmacol. Ther. 2012;92:112–117. - PMC - PubMed

[3] Wilke R.A., et al. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat. Rev. Drug Discov. 2007;6:904–916. - PMC - PubMed

[4] Wilke R.A., et al. Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges. Nat. Rev. Drug Discov. 2007;6:904–916. - PMC - PubMed

[5] Buettner C., Rippberger M.J., Smith J.K., Leveille S.G., Davis R.B., Mittleman M.A. Statin use and musculoskeletal pain among adults with and without arthritis. Am. J. Med. 2012;125:176–182. - PMC - PubMed

[6] Buettner C., Rippberger M.J., Smith J.K., Leveille S.G., Davis R.B., Mittleman M.A. Statin use and musculoskeletal pain among adults with and without arthritis. Am. J. Med. 2012;125:176–182. - PMC - PubMed

[7] Wilke R.A., Dolan M.E. Genetics and variable drug response. JAMA. 2011;306:306–307. - PMC - PubMed

[8] Wilke R.A., Dolan M.E. Genetics and variable drug response. JAMA. 2011;306:306–307. - PMC - PubMed

[9] Ramsey L.B., et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012;22:1–8. - PMC - PubMed

[10] Ramsey L.B., et al. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition. Genome Res. 2012;22:1–8. - PMC - PubMed

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The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

Affiliations

The clinical pharmacogenetics implementation consortium guideline for SLCO1B1 and simvastatin-induced myopathy: 2014 update

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