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Review
. 2014 Jun;133 Suppl 3(Suppl 3):S123-30.
doi: 10.1542/peds.2014-0122I.

Psychosocial barriers and facilitators to clinical trial enrollment and adherence for adolescents with cancer

Natasha D Buchanan  1 , Rebecca Block  2 , Ashley Wilder Smith  3 , Eric Tai  4
Affiliations
Review

Psychosocial barriers and facilitators to clinical trial enrollment and adherence for adolescents with cancer

Natasha D Buchanan et al. Pediatrics. 2014 Jun.

Abstract

Adolescents (aged 15-19 years) have not experienced the same survival gains as children and older adults diagnosed with cancer. Poor clinical trial enrollment and adherence rates among adolescents may account for some of this disparity. Although biological, regulatory, systemic, and practice-related challenges to clinical trial enrollment and adherence have been examined, studies of psychosocial factors, which can serve as barriers or facilitators to enrollment and adherence, are limited. To bring attention to these psychological factors, we reviewed existing literature on psychosocial barriers and facilitators that can affect an adolescent's decision to enroll and adhere to a clinical trial. We also provide potential strategies to address psychosocial factors affecting clinical trial accrual and adherence.

Keywords: adherence; adolescent; cancer survivors; clinical trial; enrollment; psychosocial.

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