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Meta-Analysis
. 2014 Aug 26;111(5):976-80.
doi: 10.1038/bjc.2014.294. Epub 2014 Jun 10.

Vitamin D Supplements and Cancer Incidence and Mortality: A Meta-Analysis

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Free PMC article
Meta-Analysis

Vitamin D Supplements and Cancer Incidence and Mortality: A Meta-Analysis

N Keum et al. Br J Cancer. .
Free PMC article

Abstract

Background: Observational studies suggest that effects of vitamin D may be stronger for cancer mortality than for incidence. Yet, existing randomised controlled trials (RCTs) of vitamin D supplementation have limited power to examine the relationships as their primary end points are not cancer incidence or mortality.

Methods: Meta-analyses of RCTs of vitamin D supplementation and total cancer incidence and mortality were conducted.

Results: Over 2-7 years of duration, vitamin D supplementations had little effect on total cancer incidence (400-1100 IU per day, summary relative risk (RR)=1.00, 95% confidence interval (CI)=0.94-1.06, I(2)=0%; four RCTs with combined 4333 cases), but significantly reduced total cancer mortality (400-833 IU per day, summary RR=0.88, 95% CI=0.78-0.98, I(2)=0%, three RCTs with combined 1190 deaths).

Conclusions: Over 2-7 years of duration, the benefit of vitamin D supplementation may be limited to cancer mortality.

Figures

Figure 1
Figure 1
Flowchart of study selection.
Figure 2
Figure 2
Meta-analyses of RCTs of vitamin D supplementation and total cancer incidence and mortality. (A) Total cancer incidence, (B) total cancer mortality. Abbreviations: CI=confidence interval; RR=relative risk.

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References

    1. Avenell A, MacLennan GS, Jenkinson DJ, McPherson GC, McDonald AM, Pant PR, Grant AM, Campbell MK, Anderson FH, Cooper C, Francis RM, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA. Long-term follow-up for mortality and cancer in a randomised placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial) J Clin Endocrinol Metab. 2012;97:614–622. - PubMed
    1. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–1101. - PubMed
    1. Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int. 2010;21:1121–1132. - PMC - PubMed
    1. Boscoe FP, Schymura MJ. Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer. 2006;6:264. - PMC - PubMed
    1. Chen W, Clements M, Rahman B, Zhang S, Qiao Y, Armstrong BK. Relationship between cancer mortality/incidence and ambient ultraviolet B irradiance in China. Cancer Causes Control. 2010;21:1701–1709. - PubMed
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