Two novel alleles HLA-DRB1*11:150 and HLA-DRB1*14:145 identified in Saudi individuals

Int J Immunogenet. 2014 Aug;41(4):340-1. doi: 10.1111/iji.12133. Epub 2014 Jun 12.

Abstract

Two new HLA- DRB1 alleles were identified by sequence-based typing method (SBT) in 1100 participants in the Saudi Stem Cell Donor Registry. HLA-DRB1*11:150 differs from HLA-DRB1*11:01:01G by a single C to A substitution at nucleotide position 5580 in exon 2, resulting in an amino acid change from alanine to glutamic acid at position 74. HLA-DRB1*14:145 differs from HLA-DRB1*14:04 by a C to G substitution at nucleotide position 5511 in exon 2, resulting in an amino acid change from threonine to arginine at position 51.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Amino Acid Substitution
  • Blood Donors*
  • Exons / genetics*
  • Genotype
  • HLA-DRB1 Chains / genetics*
  • Histocompatibility Testing / methods*
  • Humans
  • Molecular Sequence Data
  • Point Mutation
  • Saudi Arabia
  • Sequence Analysis, DNA / methods

Substances

  • HLA-DRB1 Chains
  • HLA-DRB1*11:01:01 antigen

Associated data

  • GENBANK/KC959380
  • GENBANK/KC959386