HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes

Arthritis Rheum. 1989 Jan;32(1):15-21. doi: 10.1002/anr.1780320104.


We examined the association of individual HLA genes with rheumatoid arthritis (RA), using oligonucleotide probes that identified both DR4-associated and non-DR4-associated genes. Two distinct HLA-DR beta alleles (Dw4 and Dw14) were found in DR4+ RA patients compared with controls (Dw4 50% versus 17%; Dw14 35% versus 5%; total DR4 73% versus 30%), indicating that these 2 alleles are independent susceptibility genes. Remarkably, the majority of the DR4- RA patients also demonstrated a linear DNA sequence, apparently "shuffled" between different susceptibility alleles, identified with an oligonucleotide probe to a key portion of the Dw14 gene.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alleles*
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology*
  • DNA Probes*
  • DNA Probes, HLA*
  • Disease Susceptibility
  • Genes, MHC Class II*
  • Genes, Overlapping
  • HLA-D Antigens / analysis*
  • HLA-DQ Antigens / analysis
  • Humans


  • DNA Probes
  • DNA Probes, HLA
  • HLA-D Antigens
  • HLA-DQ Antigens
  • HLA-DQ2 antigen
  • HLA-Dw14 antigen
  • HLA-Dw4 antigen