HSPA2 is expressed in human tumors and correlates with clinical features in non-small cell lung carcinoma patients

Anticancer Res. 2014 Jun;34(6):2833-40.


Background/aim: It has been shown that HSPA2 protein, a testis-enriched member of HSPA/HSP70 family, is important for cancer cell growth and metastasis. However, the status of HSPA2 expression in tumors and its clinical/prognostic significance are obscure. Herein we aimed to investigate the expression of HSPA2 in various types of tumors and to determine the possible clinical and prognostic significance of HSPA2 in non-small cell lung carcinoma (NSCLC).

Materials and methods: Tissue microarrays and postoperative NSCLC tumors were tested for HSPA2 by immunohistochemistry.

Results: HSPA2 is expressed in the majority of tumor histotypes. In NSCLC patients (n=85), nuclear HSPA2 expression was associated with histology, TNM staging and prognosis. High HSPA2 expression was significantly related to shorter overall survival (OS) in stage I-II patients. In multivariate analysis, high HSPA2, together with stage IIIA and male sex, were associated with shorter OS in the whole group.

Conclusions: As exemplified in NSCLC the status of HSPA2 in human tumors may have certain prognostic significance.

Keywords: HSPA2; Heat shock proteins; NSCLC; immunohistochemistry; prognosis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / metabolism*
  • Adenocarcinoma / mortality
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Non-Small-Cell Lung / metabolism*
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Carcinoma, Non-Small-Cell Lung / pathology
  • Carcinoma, Squamous Cell / metabolism*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology
  • Case-Control Studies
  • Female
  • Follow-Up Studies
  • HSP70 Heat-Shock Proteins / metabolism*
  • Humans
  • Immunoenzyme Techniques
  • Lung / metabolism
  • Lung Neoplasms / metabolism*
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Prognosis
  • Survival Rate
  • Tissue Array Analysis


  • Biomarkers, Tumor
  • HSP70 Heat-Shock Proteins
  • HSPA2 protein, human