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Review
. 2014;13(6):953-60.
doi: 10.2174/1871527313666140612114838.

Antidepressant-like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa

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Review

Antidepressant-like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa

Alexandre R de Mello Schier et al. CNS Neurol Disord Drug Targets. .

Abstract

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

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