Peroxidasins: novel players in tissue genesis

Zalán Péterfi; Miklós Geiszt

doi:10.1016/j.tibs.2014.05.005

Peroxidasins: novel players in tissue genesis

Trends Biochem Sci. 2014 Jul;39(7):305-7. doi: 10.1016/j.tibs.2014.05.005. Epub 2014 Jun 9.

Authors

Zalán Péterfi¹, Miklós Geiszt²

Affiliations

¹ Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
² Department of Physiology, Faculty of Medicine, Semmelweis University, Budapest, H-1094, Hungary; "Lendület" Peroxidase Enzyme Research Group of the Semmelweis University and the Hungarian Academy of Sciences, Budapest, Hungary. Electronic address: geiszt.miklos@med.semmelweis-univ.hu.

PMID: 24924147
DOI: 10.1016/j.tibs.2014.05.005

Abstract

Stabilization of extracellular matrix by protein crosslinking is a universal and essential process in multicellular organisms. Recent findings revealed that peroxidasin, a unique heme-peroxidase, produces hypohalides to support matrix synthesis. Unexpectedly, the highly reactive and potentially damaging hypohalides mediate the formation of sulfilimine bonds between adjacent collagen IV protomers. This crosslink is a fundamental feature of basal membranes, defining peroxidasin-dependent oxidant generation and sulfilimine crosslink formation as an elemental mechanism of tissue biogenesis.

Keywords: ROS; collagen IV; extracellular matrix; peroxidase; peroxidasin; sulfilimine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Basement Membrane / metabolism*
Collagen Type IV / chemistry
Cross-Linking Reagents / metabolism*
Extracellular Matrix Proteins / metabolism*
Humans
Peroxidase / metabolism*
Peroxidasin
Sulfur Compounds / chemistry

Substances

Collagen Type IV
Cross-Linking Reagents
Extracellular Matrix Proteins
Sulfur Compounds
Peroxidase