New cholinesterase inhibitors from Garcinia atroviridis

Fitoterapia. 2014 Sep:97:261-7. doi: 10.1016/j.fitote.2014.06.003. Epub 2014 Jun 9.

Abstract

A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.

Keywords: Cholinesterase enzymes inhibitory activity; Clusiaceae; Garcinia atroviridis; Stem bark.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / isolation & purification*
  • Flavanones / chemistry
  • Flavanones / isolation & purification*
  • Flavonols / chemistry
  • Flavonols / isolation & purification*
  • Garcinia / chemistry*
  • Molecular Docking Simulation
  • Molecular Structure
  • Plant Bark / chemistry
  • Plant Stems / chemistry

Substances

  • Cholinesterase Inhibitors
  • Flavanones
  • Flavonols
  • garcineflavanone A
  • garcineflavonol A