An unexpected role: UVA-induced release of nitric oxide from skin may have unexpected health benefits

Gary M Halliday; Scott N Byrne

doi:10.1038/jid.2014.33

An unexpected role: UVA-induced release of nitric oxide from skin may have unexpected health benefits

J Invest Dermatol. 2014 Jul;134(7):1791-1794. doi: 10.1038/jid.2014.33.

Authors

Gary M Halliday¹, Scott N Byrne²

Affiliations

¹ Dermatology, Bosch Institute, Sydney Cancer Centre, University of Sydney, Sydney, New South Wales, Australia. Electronic address: gary.halliday@sydney.edu.au.
² Dermatology, Bosch Institute, Sydney Cancer Centre, University of Sydney, Sydney, New South Wales, Australia; Infectious Diseases and Immunology, Bosch Institute, Sydney Cancer Centre, University of Sydney, New South Wales, Sydney, Australia.

PMID: 24924758
DOI: 10.1038/jid.2014.33

Abstract

UVR has deleterious and beneficial effects on human health. In this issue, Liu et al. (2014) show that UVA decreases blood pressure and increases blood flow and heart rate in humans, which is beneficial to the cardiovascular system. This is likely mediated by UVA causing release of nitric oxide (NO) from skin stores. This mediator may have additional effects on human health.

Publication types

Comment

MeSH terms

Blood Pressure / radiation effects*
Female
Humans
Male
Nitric Oxide Synthase / metabolism*
Skin / blood supply*
Skin / radiation effects*
Ultraviolet Rays*
Vasodilation / radiation effects*

Substances

Nitric Oxide Synthase