Glioblastoma in a patient with neurofibromatosis type 1: a case report and review of the literature

Brain Tumor Res Treat. 2014 Apr;2(1):36-8. doi: 10.14791/btrt.2014.2.1.36. Epub 2014 Apr 29.


Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited familial tumor syndrome. Benign tumors such as pilocytic astrocytoma, optic glioma make up the majority of intracranial neoplasms in patients with NF1. There have only been a handful of cases in which adult glioblastoma presented with NF1. A 32-year-old male presented with headache and radiological studies showing a high grade intra-axial tumor. The patient underwent gross total surgical excision and the pathology revealed glioblastoma. After the surgery, he received concomitant chemo-radiotherapy with temozolomide and adjuvant temozolomide chemotherapy. We report a NF1 patient who developed glioblastoma and reviewed related articles.

Keywords: CCRT; Glioblastoma; Neurofibromatosis type 1; Temozolomide.