Antifungal amphidinol 18 and its 7-sulfate derivative from the marine dinoflagellate Amphidinium carterae

Genoveffa Nuzzo; Adele Cutignano; Angela Sardo; Angelo Fontana

doi:10.1021/np500275x

Antifungal amphidinol 18 and its 7-sulfate derivative from the marine dinoflagellate Amphidinium carterae

J Nat Prod. 2014 Jun 27;77(6):1524-7. doi: 10.1021/np500275x. Epub 2014 Jun 13.

Authors

Genoveffa Nuzzo¹, Adele Cutignano, Angela Sardo, Angelo Fontana

Affiliation

¹ CNR, Istituto di Chimica Biomolecolare , Via Campi Flegrei 34, 80078, Pozzuoli, Naples, Italy.

PMID: 24926538
DOI: 10.1021/np500275x

Abstract

Two new polyketides of the amphidinol family, amphidinol 18 (AM18, 1) and its corresponding 7-sulfate derivative (AM19, 2), have been isolated from the MeOH extract of the dinoflagellate Amphidinium carterae. Structure elucidation of the two polyoxygenated molecules has been accomplished by extensive use of spectroscopic and spectrometric techniques. AM18 exhibited antifungal activity against Candida albicans at 9 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkenes / chemistry
Antifungal Agents / chemistry
Antifungal Agents / isolation & purification*
Antifungal Agents / pharmacology*
Candida albicans / drug effects
Dinoflagellida / chemistry*
Microbial Sensitivity Tests
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Polyketides / chemistry
Polyketides / isolation & purification*
Polyketides / pharmacology*
Pyrans / chemistry
Sulfuric Acid Esters / chemistry
Sulfuric Acid Esters / isolation & purification*

Substances

Alkenes
Antifungal Agents
Polyketides
Pyrans
Sulfuric Acid Esters
amphidinol 18
amphidinol 19
amphidinol 3