Functional gene variants of CYP3A4

Clin Pharmacol Ther. 2014 Sep;96(3):340-8. doi: 10.1038/clpt.2014.129. Epub 2014 Jun 13.


Cytochrome P450 3A4 (CYP3A4) is involved in the metabolism of more drugs in clinical use than any other foreign compound-metabolizing enzyme in humans. Recently, increasing evidence has been found showing that variants in the CYP3A4 gene have functional significance and--in rare cases--lead to loss of activity, implying tremendous consequences for patients. This review article highlights the functional consequences of all CYP3A4 variants recognized by the Human Cytochrome P450 (CYP) Allele Nomenclature Database.

Publication types

  • Review

MeSH terms

  • Cytochrome P-450 CYP3A / genetics*
  • Cytochrome P-450 CYP3A / metabolism*
  • Drug Interactions
  • Drug-Related Side Effects and Adverse Reactions / enzymology
  • Drug-Related Side Effects and Adverse Reactions / genetics
  • Genotype
  • Humans
  • Patient Safety
  • Pharmacogenetics*
  • Pharmacokinetics
  • Phenotype
  • Polymorphism, Genetic*
  • Precision Medicine
  • Risk Assessment
  • Risk Factors


  • Cytochrome P-450 CYP3A
  • CYP3A4 protein, human