Genome-wide profiling reveals a role for T-cell intracellular antigens TIA1 and TIAR in the control of translational specificity in HeLa cells

Biochem J. 2014 Jul 1;461(1):43-50. doi: 10.1042/BJ20140227.


TIA (T-cell intracellular antigens)-knockdown HeLa cells show an increase in ribosomes and translational machinery components. This increase correlates with specific changes in translationally up-regulated mRNAs involved in cell-cycle progression and DNA repair, as shown in polysomal profiling analysis. Our data support the hypothesis that a concerted activation of both global and selective translational rates leads to the transition to a more proliferative status in TIA-knockdown HeLa cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Profiling / methods*
  • Genome-Wide Association Study / methods*
  • HeLa Cells
  • Humans
  • Intracellular Fluid* / immunology
  • Poly(A)-Binding Proteins / genetics
  • Poly(A)-Binding Proteins / physiology*
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / physiology*
  • T-Cell Intracellular Antigen-1
  • T-Lymphocytes / chemistry
  • T-Lymphocytes / immunology*
  • Transcriptional Activation* / immunology


  • Poly(A)-Binding Proteins
  • RNA-Binding Proteins
  • T-Cell Intracellular Antigen-1
  • TIA1 protein, human
  • TIAL1 protein, human

Associated data

  • GEO/GSE54540