Segmented negative-strand RNA viruses and RIG-I: divide (your genome) and rule

Curr Opin Microbiol. 2014 Aug;20:96-102. doi: 10.1016/j.mib.2014.05.002. Epub 2014 Jun 13.


The group of negative-stranded RNA viruses (NSVs) with a segmented genome comprises pathogens like influenza virus (eight segments), Rift Valley fever virus and Hantavirus (three segments), or Lassa virus (two segments). Partitioning the genome allows rapid evolution of new strains by reassortment. Each segment carries a short double-stranded (ds) 'panhandle' structure which serves as promoter. Similar dsRNA structures, however, represent the optimal ligand for RIG-I, a cytoplasmic pathogen sensor of the antiviral interferon response. Thus, segmenting a virus genome can entail an increased RIG-I sensitivity. Here, we outline the astonishingly diverse and efficient strategies by which segmented NSVs are compensating for the elevated number of RIG-I ligands in their genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD-box RNA Helicases / immunology
  • DEAD-box RNA Helicases / metabolism*
  • Humans
  • Immune Evasion
  • Immunity, Innate*
  • RNA Viruses / immunology*
  • RNA, Double-Stranded / immunology
  • RNA, Double-Stranded / metabolism*
  • RNA, Viral / immunology
  • RNA, Viral / metabolism*
  • Receptors, Immunologic / immunology
  • Receptors, Immunologic / metabolism*


  • RNA, Double-Stranded
  • RNA, Viral
  • Receptors, Immunologic
  • DEAD-box RNA Helicases