2-Aminobenzoxazole ligands of the hepatitis C virus internal ribosome entry site

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3521-5. doi: 10.1016/j.bmcl.2014.05.088. Epub 2014 Jun 4.

Abstract

2-Aminobenzoxazoles have been synthesized as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The compounds were designed to explore the less basic benzoxazole system as a replacement for the core scaffold in previously discovered benzimidazole viral translation inhibitors. Structure-activity relationships in the target binding of substituted benzoxazole ligands were investigated.

Keywords: Antivirals; HCV; RNA target; Translation inhibitor.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology*
  • Benzoxazoles / chemical synthesis
  • Benzoxazoles / chemistry
  • Benzoxazoles / pharmacology*
  • Hepacivirus / chemistry
  • Hepacivirus / drug effects*
  • Ligands
  • Models, Molecular
  • Molecular Structure
  • RNA, Viral / antagonists & inhibitors*
  • RNA, Viral / metabolism
  • Ribosomes / drug effects*
  • Ribosomes / metabolism

Substances

  • Antiviral Agents
  • Benzoxazoles
  • Ligands
  • RNA, Viral