Abstract
Injection of cysts of avirulent strains of T. gondii intraperitoneally into mice that were pretreated with monoclonal antibody against interferon-gamma (IFN-gamma) provided more than 10(7) trophozoites of those strains. This method is suitable for obtaining large numbers of trophozoites of T. gondii strains that are avirulent for mice.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal
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Female
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Interferon-gamma / immunology*
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Methods
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Mice
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Mice, Inbred BALB C
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Recombinant Proteins
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Toxoplasma / isolation & purification*
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Toxoplasma / pathogenicity
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Virulence
Substances
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Antibodies, Monoclonal
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Recombinant Proteins
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Interferon-gamma