Pediatric transplantation and tolerance: past, present, and future

Pediatr Transplant. 2014 Aug;18(5):435-45. doi: 10.1111/petr.12301. Epub 2014 Jun 14.

Abstract

Solid organ transplantation is the treatment of choice in children with end-stage organ failure. With improving methods of transplant surgery and post-transplant care, transplantation is more frequently performed worldwide. However, lifelong and non-specific suppression of the recipient's immune system is a cause of significant morbidity in children, including infection, diabetes, and cancer. There is a great need to develop IS minimization/withdrawal and tolerance induction approaches.

Keywords: tolerance; transplantation.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Apoptosis
  • Biomarkers
  • Child
  • Graft Rejection / immunology
  • Hematopoietic Stem Cells / cytology
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Immune System
  • Immune Tolerance
  • Immunosuppression / adverse effects*
  • Immunosuppression / methods
  • Immunosuppressive Agents / adverse effects*
  • Immunosuppressive Agents / therapeutic use
  • Organ Transplantation / history
  • Organ Transplantation / trends*
  • Pediatrics
  • Steroids / adverse effects
  • Treatment Outcome

Substances

  • Biomarkers
  • Immunosuppressive Agents
  • Steroids