Rapid and efficient one-pot synthesis of spiro[indoline-3,4'-pyrano[2, 3-c]pyrazole] derivatives catalyzed by l-proline under ultrasound irradiation

Wang Liju; Keyume Ablajan; Feng Jun

doi:10.1016/j.ultsonch.2014.05.013

Rapid and efficient one-pot synthesis of spiro[indoline-3,4'-pyrano[2, 3-c]pyrazole] derivatives catalyzed by l-proline under ultrasound irradiation

Ultrason Sonochem. 2015 Jan:22:113-8. doi: 10.1016/j.ultsonch.2014.05.013. Epub 2014 Jun 2.

Authors

Wang Liju¹, Keyume Ablajan², Feng Jun¹

Affiliations

¹ College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, PR China.
² College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, PR China. Electronic address: ablajan209@hotmail.com.

PMID: 24931425
DOI: 10.1016/j.ultsonch.2014.05.013

Abstract

A rapid and efficient ultrasound-promoted one-pot synthesis of spiro[indoline-3,4'-pyrano[2,3-c]pyrazole] derivatives is described here. The reaction of substituted phenylhydrazine and dialkyl acetylenedicarboxylate with substituted isatin and malononitrile is catalyzed by l-proline to give good-to-excellent yields in water/ethanol (v/v, 1:1) at room temperature.

Keywords: Multi-component reaction; One-pot synthesis; Spiropyranopyrazoles; Ultrasound irradiation.

Publication types

Research Support, Non-U.S. Gov't