P300 aberration in first-episode schizophrenia patients: a meta-analysis

Yao-qin Qiu; Yun-xiang Tang; Raymond C K Chan; Xin-yang Sun; Jia He

doi:10.1371/journal.pone.0097794

P300 aberration in first-episode schizophrenia patients: a meta-analysis

PLoS One. 2014 Jun 16;9(6):e97794. doi: 10.1371/journal.pone.0097794. eCollection 2014.

Authors

Yao-qin Qiu¹, Yun-xiang Tang², Raymond C K Chan³, Xin-yang Sun³, Jia He⁴

Affiliations

¹ School of Nursing, Second Military Medical University, Shanghai, P.R. China; Department of Statistics, Faculty of Medical Services, Second Military Medical University, Shanghai, P.R. China.
² Department of Medical Psychology, Faculty of psychology and mental healthy, Second Military Medical University, Shanghai, P.R. China.
³ Neuropsychology and Applied Cognitive Neuroscience Laboratory, Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, P.R. China.
⁴ Department of Statistics, Faculty of Medical Services, Second Military Medical University, Shanghai, P.R. China.

Abstract

Background: Decreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial.

Methods: A meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation.

Results: A total of 569 FES patients and 747 HCs were included in this meta-analysis. P300 amplitude was significantly reduced (PSES = -0.83, 95% CI: -1.02-0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = -0.48, 95% CI: 0.14-0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity.

Conclusions: The meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Event-Related Potentials, P300*
Female
Humans
Male
Psychiatric Status Rating Scales
Regression Analysis
Schizophrenia / physiopathology*

Grants and funding

The Ministry of Science and Technology of China (2008ZX10002-007, 2008ZX10002-018, 2008ZX10002-025), The Leading Talents of Science in Shanghai 2010 (022), The Key Discipline Construction of Evidence-Based Public Health in Shanghai (12GWZX0602), The National Science Foundation of China (81373105, 81088001,81372122), The Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.