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, 38 (1), 48-56

Psychological States, Serum Markers and Survival: Associations and Predictors of Survival in Patients With Renal Cell Carcinoma

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Psychological States, Serum Markers and Survival: Associations and Predictors of Survival in Patients With Renal Cell Carcinoma

Sarah Prinsloo et al. J Behav Med.

Abstract

This study sought to determine if there was an association between prognostic-based serum biomarkers, survival, and psychosocial factors in patients with metastatic renal cell carcinoma. Associations were found between psychosocial factors and biomarker levels (hemoglobin with depressive symptoms (r = -0.29), positive affect (r = 0.30), social support (r = 0.19), and perceived stress (r = -0.27); albumin with depressive symptoms (r = -0.19), positive affect (r = 0.22), and social support (r = 0.20); alkaline phosphatase with depressive symptoms (r = 0.21), all p values <0.05. After adjustment for disease-related risk factors, only the associations between positive affect and perceived stress with hemoglobin remained significant (p's < 0.05). Positive affect (HR = 0.90; 95% CI = 0.83, 0.97; p = 0.009) and depressive symptom total scores (HR = 1.03; 95% CI = 1.01, 1.06; p = 0.013), and alkaline phosphatase (HR 2.72; 95% CI = 1.41, 5.24; p = 0.003) were associated with survival. This study suggests that measures of positive and negative psychological outlook may contribute differently to health, well-being, and survival.

Conflict of interest statement

Conflicts of interest Sarah Prinsloo, Qi Wei, Shellie M. Scott, Nizar Tannir, Eric Jonasch, Louis Pisters and Lorenzo Cohen declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Kaplan–Meier survival curves examining the joint effect of positive affect and depressive symptoms

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