Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology
- PMID: 24936031
- DOI: 10.1093/ilar/ilu009
Canine osteosarcoma: a naturally occurring disease to inform pediatric oncology
Abstract
Osteosarcoma (OSA) is the most common form of malignant bone cancer in children and dogs, although the disease occurs in dogs approximately 10 times more frequently than in people. Multidrug chemotherapy and aggressive surgical techniques have improved survival; however, new therapies for OSA are critical, as little improvement in survival times has been achieved in either dogs or people over the past 15 years, even with significant efforts directed at the incorporation of novel therapeutic approaches. Both clinical and molecular evidence suggests that human and canine OSA share many key features, including tumor location, presence of microscopic metastatic disease at diagnosis, development of chemotherapy-resistant metastases, and altered expression/activation of several proteins (e.g. Met, ezrin, phosphatase and tensin homolog, signal transducer and activator of transcription 3), and p53 mutations, among others. Additionally, canine and pediatric OSA exhibit overlapping transcriptional profiles and shared DNA copy number aberrations, supporting the notion that these diseases are similar at the molecular level. This review will discuss the similarities between pediatric and canine OSA with regard to histology, biologic behavior, and molecular genetic alterations that indicate canine OSA is a relevant, spontaneous, large animal model of the pediatric disease and outline how the study of naturally occurring OSA in dogs will offer additional insights into the biology and future treatment of this disease in both children and dogs.
Keywords: comparative oncology; dog; naturally occurring cancer models; osteosarcoma.
© The Author 2014. Published by Oxford University Press on behalf of the Institute for Laboratory Animal Research. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Similar articles
-
Biology, diagnosis and treatment of canine appendicular osteosarcoma: similarities and differences with human osteosarcoma.Vet J. 2011 Sep;189(3):268-77. doi: 10.1016/j.tvjl.2010.08.014. Epub 2010 Oct 2. Vet J. 2011. PMID: 20889358 Review.
-
Investigating CXCR4 expression in canine appendicular osteosarcoma.J Vet Intern Med. 2008 May-Jun;22(3):602-8. doi: 10.1111/j.1939-1676.2008.0089.x. Epub 2008 May 2. J Vet Intern Med. 2008. PMID: 18466248
-
Comparative Immunology and Immunotherapy of Canine Osteosarcoma.Adv Exp Med Biol. 2020;1258:199-221. doi: 10.1007/978-3-030-43085-6_14. Adv Exp Med Biol. 2020. PMID: 32767244 Review.
-
Of dogs and men: comparative biology as a tool for the discovery of novel biomarkers and drug development targets in osteosarcoma.Pediatr Blood Cancer. 2012 Mar;58(3):327-33. doi: 10.1002/pbc.23341. Epub 2011 Oct 11. Pediatr Blood Cancer. 2012. PMID: 21990244 Review.
-
HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors.BMC Vet Res. 2013 Jul 1;9:130. doi: 10.1186/1746-6148-9-130. BMC Vet Res. 2013. PMID: 23816051 Free PMC article.
Cited by
-
Translation of oncolytic viruses in sarcoma.Mol Ther Oncol. 2024 Jun 5;32(3):200822. doi: 10.1016/j.omton.2024.200822. eCollection 2024 Sep 19. Mol Ther Oncol. 2024. PMID: 39040851 Free PMC article. Review.
-
Comparative responses to demethylating therapy in animal models of osteosarcoma.Res Sq [Preprint]. 2024 Jun 11:rs.3.rs-4451060. doi: 10.21203/rs.3.rs-4451060/v1. Res Sq. 2024. PMID: 38946977 Free PMC article. Preprint.
-
Immunohistochemical Investigation into Protein Expression Patterns of FOXO4, IRF8 and LEF1 in Canine Osteosarcoma.Cancers (Basel). 2024 May 20;16(10):1945. doi: 10.3390/cancers16101945. Cancers (Basel). 2024. PMID: 38792023 Free PMC article.
-
Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma.Res Sq [Preprint]. 2024 Apr 11:rs.3.rs-4223759. doi: 10.21203/rs.3.rs-4223759/v1. Res Sq. 2024. PMID: 38659878 Free PMC article. Preprint.
-
Bringing the Genomic Revolution to Comparative Oncology: Human and Dog Cancers.Annu Rev Biomed Data Sci. 2024 Aug;7(1):107-129. doi: 10.1146/annurev-biodatasci-102423-111936. Epub 2024 Jul 24. Annu Rev Biomed Data Sci. 2024. PMID: 38648188 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous
