Feeding regulation in Drosophila

Curr Opin Neurobiol. 2014 Dec;29:57-63. doi: 10.1016/j.conb.2014.05.008. Epub 2014 Jun 14.


Neuromodulators play a key role in adjusting animal behavior based on environmental cues and internal needs. Here, we review the regulation of Drosophila feeding behavior to illustrate how neuromodulators achieve behavioral plasticity. Recent studies have made rapid progress in determining molecular and cellular mechanisms that translate the metabolic needs of the fly into changes in neuroendocrine and neuromodulatory states. These neuromodulators in turn promote or inhibit discrete feeding behavioral subprograms. This review highlights the links between physiological needs, neuromodulatory states, and feeding decisions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cues
  • Drosophila / physiology*
  • Environment*
  • Feeding Behavior / physiology*
  • Neurotransmitter Agents / metabolism*


  • Neurotransmitter Agents